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- W2368984780 abstract "[Objective] To investigate the expression of human caspase-3 in human laryngeal cancer, and to explore the relationship between its expression and clinical pathology biological factors including lymph node metastasis and prognosis of human laryngeal squamous cell cancer. [Method] The expression of caspase-3 was studied using two-step immunohistochemistry method with antibody against caspase-3 protein in paraffin-embedded specimens of 68 cases with primary laryngeal cancer tissue and 10 cases with neighboring noncancerous normal epithelial tissue. [Result] Human caspase-3 protein expressive rate was 50.0% in laryngeal cancer tissue. The positive rate is 45.83% (22/48) and 60.0% (12/20) seperately among supraglottic laryngeal carcinoma and glottis laryngocarcinoma. A significant negative correlation was found between lymphatic metastasis and caspase-3 positive expression(P 0.05). [Conclusion] caspase-3 might play an important role in the development of invasion and metastasis of the laryngeal cancer. It was indicated that patients with caspase-3 negative expression would have a greater chance of metastasis with a poorer prognosis." @default.
- W2368984780 created "2016-06-24" @default.
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- W2368984780 date "2007-01-01" @default.
- W2368984780 modified "2023-09-26" @default.
- W2368984780 title "Expression of Caspase-3 protein and clinical significance in human laryngeal cancer" @default.
- W2368984780 hasPublicationYear "2007" @default.
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