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- W2368997966 abstract "Objective This study is aimed at comparing the effect of two Chinese traditional drugs,Dauricine and Tetrandrine, on the myocardial electrophysiology and the sarcoplasmic reticulum Ca 2+ ATPase. Methods Changes of AP、dV/dt、PT and dT/dt of myocardial cells were studied by using the technique of glass electrode,and changes of the calcium uptake rate by sarcoplasmic reticulum and release of inorganic phosphate from sarcoplasmic reticulum were assessed with biochemical techniques after administration. Results Dauricine has the effect of prolonging the APD 20 ,APD 90 of FAP and the APD 90 of SAP,particularly widening APD 90 ( P 0.05), but the APD 20 of SAP is shortened.Although tetrandrine prolongs slightly the APD 90 of FAP(No statistic difference),it shortens obviously the APD 20 and APD 90 of SAP.Both drugs inhibit APA、PT、dT/dt and absorption rate of calcium and release of inorganic phosphate.The action of the latter four items are more evident with the use of tetrandrine. Conclusion Dauricine slightly inhibits the calcium influx and activity of Ca 2+ ATPase,but evidently inhibits the sodium influx and potassium efflux,especially delayed potassium efflux blocked.The electrophysiologic mechanism is similar to that of a class Ⅲ anti arrhythmic drug amiodarone." @default.
- W2368997966 created "2016-06-24" @default.
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- W2368997966 date "1999-01-01" @default.
- W2368997966 modified "2023-10-03" @default.
- W2368997966 title "The effect of dauricine on the myocardial electrophysiology and the Ca~(2+) ATP ase of sarcoplasmic reticulum in comparison with the action of tetrandrine" @default.
- W2368997966 hasPublicationYear "1999" @default.
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