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- W2369001046 abstract "Objective: Our purpose was to investigate the relationship between hepatitis C virus (HCV) hypervariable region 1 (HVR1) and nonstructural protein 5A(NS5A) quasispecies complexity and the effectiveness to interferon (IFN) therapy in patients with HCV 1b infection.Methods: Dynamic changes of HCV quasispecies before and after IFN therapy were detected by the method of polymerase chain reaction-mediated single-strand conformation polymorphism (SSCP).Results: The complexity of HVR1 quasispecies in responders was less than that in nonresponders before IFN treatment,whereas the complexity of NS5A quasispecies was not different between the 2 groups. Numbers of SSCP bands of HVR1 were decreased after IFN therapy in most patients.Conclusion: The low complexity of HCV HVR1 quasispecies indicates the effectiveness of IFN therapy in patients with HCV 1b infection. No correlation exists between the complexity of NS5A quasispecies and the effectiveness of IFN therapy." @default.
- W2369001046 created "2016-06-24" @default.
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- W2369001046 date "2003-01-01" @default.
- W2369001046 modified "2023-09-25" @default.
- W2369001046 title "Relationship Between Hepatitis C Virus Quasispecies Complexity and Response to Interferon Therapy" @default.
- W2369001046 hasPublicationYear "2003" @default.
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