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- W2369012539 abstract "Aim To investigate the effects of peripheral tissue injury on the synaptic contents of AMPA receptor in spinal dorsal horn and its underlying molecular mechanisms.Methods Complete Freund's Adjuvant(CFA) was injected into the plantar surface of mouse hindpaws to induce inflammatory pain.24 h later,PSD-enriched fraction was isolated from L4-L5 spinal dorsal horn for immunoblotting analysis of the synaptic content of GluR2.The role of cAMP-dependent protein kinase(PKA) in the regulation of synaptic GluR2 was also investigated.Results CFA simultaneously induced the mechanical allodynia and the increase in the synaptic amount of GluR2 in spinal dorsal horn.Although PKA inhibitor H-89 generated minimal effects on the Paw Withdrawal Threshold and synaptic GluR2 amount in intact mice,it dramatically repressed GluR2 synaptic concentration in inflamed mice,which was coincident with the alleviation of allodynia.Conclusion Peripheral tissue injury evokes aberrant increase in the synaptic contents of AMPA receptor GluR2 subunits in spinal dorsal horn via PKA signaling,which is closely involved in the induction of chronic inflammatory pain." @default.
- W2369012539 created "2016-06-24" @default.
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- W2369012539 date "2011-01-01" @default.
- W2369012539 modified "2023-09-26" @default.
- W2369012539 title "Effects of peripheral tissue injury on the synaptic expression of spinal AMPA receptors and its underlying mechanisms" @default.
- W2369012539 hasPublicationYear "2011" @default.
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