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- W2369014148 abstract "Objective To study the common chemotherapy effect and its mechanisms of the adaptive response induced by low dose BLMA 5 (0 08 mg·kg -1 , D 1) on a Kunming S180 sarcoma mouse model made through subcutaneous injection. Methods D 1 was given to tumor bearing mice before chemotherapy, the growth of tumor was observed, chromosomal samples of bone marrow cells of mice were prepared and the activities of free radicals of liver were measured. Results The grow velocity was significantly decreased ( P 0 05~0 001), the chromosome aberrations of bone marrow cells were significantly reduced ( P 0 01), SOD activity of liver was increased markedly ( P 0 05), the activity of GSH Px also had the trend of increasing and the content of MDA decreased significantly ( P 0 01) when D 1 was given to the tumor bearing mouse before larger dose BLMA 5(D 2) chemotherapy. Conclusion The chemotherapy effect enhanced with low dose BLMA 5 is associated with the increase of antioxidant capacity and the elimination capacity of free radicals products." @default.
- W2369014148 created "2016-06-24" @default.
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- W2369014148 date "2004-01-01" @default.
- W2369014148 modified "2023-09-25" @default.
- W2369014148 title "Antitumor effect of low dose BLMA_5 and its mechanisms" @default.
- W2369014148 hasPublicationYear "2004" @default.
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