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- W2369034493 abstract "Objective To discuss the correlation of many dynamic MRI features with nuclear DNA content and pathology in hepatocellular carcinomas.Materials and Methods 43 patients with pathologically confirmed HCC were reviewed. The enhancement types of HCC were classified into four categories. Type Ⅰ: hyper or isointensity on arterial phase (AP) and hypointensity on portal phase (PP); type Ⅱ: hyper or isointensity on both AP and PP; type Ⅲ: hypointensity on AP and iso or hyperintensity on PP; type Ⅳ: hypointensity on both AP and PP. Enhancement type, pattern and of enhancement on AP, size, capsule, necrosis, satellite nodules and the portal vein embolus of HCC were analyzed. DNA index (DI) was measured by Flow Cytometry with paraffin embedded specimens of HCC. The relationship between MRI features and nuclear DNA content of HCC was analyzed.Results Of 43 cases, there were 29 cases of enhancement type Ⅰ, 12 cases of type Ⅱ, each one of type Ⅲ and type Ⅳ. DI of enhancement type Ⅰ was significantly higher than that of type Ⅱ (P=0.009). The statistical differences were existed between DI of HCC with peripheral and nonperipheral enhancement (P=0.005), markedly and slightly enhancement (P=0.038), homogeneous and inhomogeneous enhancement (P0.001). DI of tumor with diameter5.0 cm, necrosis, embolus, satellite nodules and without tumor capsule were significantly higher than that of tumor diameter 3.0 cm (P=0.002), without tumor necrosis (P=0.026) and embolus (P=0.005) or satellite nodules (P=0.005), with capsule (P=0.027). There were no differences for DI of HCC between tumor diameter3.0 cm and diameter in 3.0～5.0 cm (P=0.192), between tumor diameter in 3.0～5.0 cm and diameter5.0 cm (P=0.084). Tumor size, tumor capsule, enhancement type and enhancement pattern were correlated with DI by multiple linear regression's analysis, regression formula was Y=-1.678+0.279X_1+0.534X_2+ 0.668X_3+ 0.427X_4. DI of HCC in Grade Ⅲ, Ⅳ was higher than that in Grade Ⅰ, Ⅱ (P=0.001).Conclusion The features of dynamic MRI are correlated with nuclear DNA content and the pathology, which could indirectly reflect the malignant biological behavior of HCC." @default.
- W2369034493 created "2016-06-24" @default.
- W2369034493 creator A5006307574 @default.
- W2369034493 date "2006-01-01" @default.
- W2369034493 modified "2023-09-23" @default.
- W2369034493 title "Linear Regression Analysis on Many Dynamic MRI Features with Nuclear DNA Content in Hepatocellular Carcinomas" @default.
- W2369034493 hasPublicationYear "2006" @default.
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