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- W2369041483 abstract "Objective:To investigate the clinical significance of Sialyl Lewis-X (SLeX) antigen in liver metastases of human colon carcinoma.Methods:Observing the adhesive potential of Lovo and HT29 cell to human umbilical vein endothelium and endothelial cell and alteration of the adhesive potential after colon carcinoma cells were sealed by SLeX monoclonal antibody by means of the adhesive test in which a scanning electronic microscope and a transmission electronic microscope were used; observing the effects of SLeX monoclonal antibody on hepatic metastases of colon carcinoma in the experimental nude mice before and after the Lovo and HT29 cells were sealed by SLeX monoclonal antibody.Results:Lovo cells with high expressive SLeX antigen contained more powerful adhesive potential to umbilical vein endothelium than that of HT29 cells to low metastases potential. The link between Lovo cells and umbilical vein endothelial cells was significantly different from that between HT29 cells and umbilical vein endothelial cells. The Lovo cells with the high expression of SLeX antigen showed a higher hepatic metastases rate in nude mice than HT29 cells with low expression of SLeX antigen.Conclusion:The colon carcinoma cell surface SLeX antigen played an important role both in adhesion between colon carcinoma cells and umbilical vein endothelial cells and in hepatic metastases in experimental nude mice. The SLeX monoclonal antibody could restrain adhesion between tumor cells and vein endothelial cells and reduce hepatic metastases formation in experimental nude mice." @default.
- W2369041483 created "2016-06-24" @default.
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- W2369041483 date "2006-01-01" @default.
- W2369041483 modified "2023-09-23" @default.
- W2369041483 title "Clinical significance of Sialyl Lewis-X antigen in liver metastases of human colon carcinoma" @default.
- W2369041483 hasPublicationYear "2006" @default.
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