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- W2369048446 abstract "Objective To estimate the radiation absorbed doses of 131I-RRL in human being by analyzing its biologic distribution in mice,and to discuss its pharmacokinetics in big ear rabbits.Methods 131I-RRL was injected into 40mice via lateral tail vein,and then its biodistribution was observed in different time points,and the radiation dosimetry of 131I-RRL in human being was calculated according to the organ distribution in mouse.Another 4mice were used for SPECT,while 5 rabbits were used in pharmacokinetic observation.Results Early after injection of 131I-RRL,the radioactivity in tumorburdened mice mainly distributed in kidneys and bladder,while in blood declined quickly.With time going,the ratio of target tissue and nontarget tissue became higher in mice.SPECT showed that radioactivity in tumor tissue was higher than in other organs or tissue.Only tumor gathered radiation after 24h.Absorption effective dose in adult body was 0.0293mSv/ MBq.The pharmacokinetics of rabbits was 2room model,distribution of half-life was(0.32+0.07)h,remove phase halflife was(33.15+5.67)h.Conclusion 131I-RRL is a safe means of imaging agent,which has fast absorption and slow clearance speed in the body,and may be used in target therapy of tumors." @default.
- W2369048446 created "2016-06-24" @default.
- W2369048446 creator A5065737137 @default.
- W2369048446 date "2014-01-01" @default.
- W2369048446 modified "2023-09-23" @default.
- W2369048446 title "Radiation dose and pharmacokinetic analysis of molecular probe ~(131)I-RRL targeting tumor angiogenesis" @default.
- W2369048446 hasPublicationYear "2014" @default.
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