Matches in SemOpenAlex for { <https://semopenalex.org/work/W2369075718> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2369075718 abstract "Objective The study aims to explore the protective effects of carvedilol on the adriamycin-induced rat cardiotoxicity and to explore its possible mechanism.Methods Wistar rats weighing(270±10)g were randomly divided into three groups(n=12 in every group):adriamycin group,carvedilol group and control group.Adriamycin(2.5 mg/kg) was administered to rats in eight equal intraperitoneal injections over a period of 2 weeks(cumulative dose of 20 mg/kg)in adriamycin group and normal saline(30 mg/kg daily) was administered orally in twe equal doses every days over a 8-week period.Carvedilol(30 mg/kg daily) was administered orally in two equal doses every day over a 8-week period with adriamycin treatment in carvedilol group.The equivalent volume of normal saline was used in control group.In 9 week,the changes of rat cardiac function,the activity of superoxide dismutase and the contents of malondialdehyde in serum as well as myocardial cell apotosis were detected.Results(1) Hemodynamic effects:Compared with the control group,hemodynamic parameters in the adriamycin group were deteriorated(P0.05).Compared with adriamycin group,±dp/dtmas were increased(P0.05) and LVEDP was decreased(P0.05) in the carvedilol group,but there was no significant difference in LVSP and MAP were not different from that in the adriamycin group(P0.05).Defference in ±dp/dtmax and LVEDP in the carvedilol group and control group were not significant(P0.05).(2)The activity of superoxide dismutase and the contents of malondialdehyde in serum.The activity of superoxide dismutase in the carvedilol group was enhanced significantly compared with that in the adriamycin group(P0.05),the contents of malondialdehyde in the carvedilol group were decreased significantly compared with that in the adriamycin group(P0.05).Diference in activity of superoxide dismutase and the contents of malondialdehyde between the carvedilol group and control group was not significant(P0.05).(3) Cardiomyocyte apoptosis:Cardiomyocyte apoptosis in the adriamycin group were significantly increased compared with that in the control group (P0.05),but cardiomyocyte apoptosis in the carvedilol group was lower than that in the adriamycin group(P0.05).Conclusion(1)Carvedilol relieves adriamycin-induced hemodynamic abnormality mainly by improving cardiac systolic and diastolic function.(2)Carvedilol prevents adriamycin-induced excessive oxidative stress.(3)Carvedilol suppresses cardiomyocyte apoptosis is induced by adriamycin." @default.
- W2369075718 created "2016-06-24" @default.
- W2369075718 creator A5081452702 @default.
- W2369075718 date "2007-01-01" @default.
- W2369075718 modified "2023-09-26" @default.
- W2369075718 title "The Protective Effects of Carvedilol on the Adriamycin-induced Cardiotoxicity" @default.
- W2369075718 hasPublicationYear "2007" @default.
- W2369075718 type Work @default.
- W2369075718 sameAs 2369075718 @default.
- W2369075718 citedByCount "0" @default.
- W2369075718 crossrefType "journal-article" @default.
- W2369075718 hasAuthorship W2369075718A5081452702 @default.
- W2369075718 hasConcept C126322002 @default.
- W2369075718 hasConcept C178853913 @default.
- W2369075718 hasConcept C2775838275 @default.
- W2369075718 hasConcept C2776151105 @default.
- W2369075718 hasConcept C2776694085 @default.
- W2369075718 hasConcept C2777397205 @default.
- W2369075718 hasConcept C2778198053 @default.
- W2369075718 hasConcept C2778233292 @default.
- W2369075718 hasConcept C2778401633 @default.
- W2369075718 hasConcept C2780591200 @default.
- W2369075718 hasConcept C42219234 @default.
- W2369075718 hasConcept C48277249 @default.
- W2369075718 hasConcept C71924100 @default.
- W2369075718 hasConcept C98274493 @default.
- W2369075718 hasConceptScore W2369075718C126322002 @default.
- W2369075718 hasConceptScore W2369075718C178853913 @default.
- W2369075718 hasConceptScore W2369075718C2775838275 @default.
- W2369075718 hasConceptScore W2369075718C2776151105 @default.
- W2369075718 hasConceptScore W2369075718C2776694085 @default.
- W2369075718 hasConceptScore W2369075718C2777397205 @default.
- W2369075718 hasConceptScore W2369075718C2778198053 @default.
- W2369075718 hasConceptScore W2369075718C2778233292 @default.
- W2369075718 hasConceptScore W2369075718C2778401633 @default.
- W2369075718 hasConceptScore W2369075718C2780591200 @default.
- W2369075718 hasConceptScore W2369075718C42219234 @default.
- W2369075718 hasConceptScore W2369075718C48277249 @default.
- W2369075718 hasConceptScore W2369075718C71924100 @default.
- W2369075718 hasConceptScore W2369075718C98274493 @default.
- W2369075718 hasLocation W23690757181 @default.
- W2369075718 hasOpenAccess W2369075718 @default.
- W2369075718 hasPrimaryLocation W23690757181 @default.
- W2369075718 hasRelatedWork W179271689 @default.
- W2369075718 hasRelatedWork W1998008679 @default.
- W2369075718 hasRelatedWork W2019192827 @default.
- W2369075718 hasRelatedWork W2071602603 @default.
- W2369075718 hasRelatedWork W2313193404 @default.
- W2369075718 hasRelatedWork W2347538803 @default.
- W2369075718 hasRelatedWork W2348495391 @default.
- W2369075718 hasRelatedWork W2349089697 @default.
- W2369075718 hasRelatedWork W2350819018 @default.
- W2369075718 hasRelatedWork W2352373960 @default.
- W2369075718 hasRelatedWork W2356316039 @default.
- W2369075718 hasRelatedWork W2374675257 @default.
- W2369075718 hasRelatedWork W2375310413 @default.
- W2369075718 hasRelatedWork W2378565091 @default.
- W2369075718 hasRelatedWork W2379138140 @default.
- W2369075718 hasRelatedWork W2386634975 @default.
- W2369075718 hasRelatedWork W2391400099 @default.
- W2369075718 hasRelatedWork W2392402141 @default.
- W2369075718 hasRelatedWork W3030618948 @default.
- W2369075718 hasRelatedWork W3032079442 @default.
- W2369075718 isParatext "false" @default.
- W2369075718 isRetracted "false" @default.
- W2369075718 magId "2369075718" @default.
- W2369075718 workType "article" @default.