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- W2369097019 abstract "Objective To study the relation between the expression of CD44V6, p53 and PCNA and the prognosis of colorectal carcinoma. Methods Immnohistochemical method was used to detect the expression or CD44V6, p53 and PCNA in 51 patients with colorectal cacinoma.Results The positive rate of CD44V6 was 41.18%(21/51). It was 53.85%(7/13) in low differentiated colorectal carcinoma,markedly higher than that in highly differemtiated carcinoma (36.84%,7/19)( P 0 05) The expression rate outside of serosa was 53.34%(8/15), markedly higher than that in muscular layer (33.33%,2/6)( P 0 05)Also, it was much higher in carcinoma with lymph node metastasis (63.16%, 12/19) than that in carcinoma without lymph node metastasis (31.25 %,10/32)( P 0 05).The positive rate of p53 was (50.59% 26/51) and was only related with the depth of infiltration of carcinoma. The expression of p53 in the outer layer of serosa was (53.33%, 8/15),apparently higher than that in muscular layer (33.33%,2/6)( P 0 05),while the expression of PCNA was not related to pathological grade, depth of infiltration and lymph node metastasis ( P 0 05).Conclusion The expression of CD44V6 and p53 is correlated with progression and metastasis of colorectal carcinoma, so CD44V6 and p53 may be used as a hopeful marker for predicting the metastastic potential of colorectal carcinoma and the prognosis of these patients." @default.
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- W2369097019 date "2000-01-01" @default.
- W2369097019 modified "2023-09-23" @default.
- W2369097019 title "RELATIONSHIP BETWEEN EXPRESSION OF CD44V6,P53,PCNA AND THE PROGNOSIS OF COLORECTAL CARCINOMA" @default.
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