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- W2369098587 abstract "Objective:To explore the mechanism of Bushen Yifei Xiaozheng Formula in the treatment of idiopathic pulmonary fibrosis(IPF).Methods:The IPF rats were caused by bleomycin and treated by Bushen Yifei Xiaozheng Formula.The contents of interleukin-4(IL-4) in serum of rats were detected by enzyme linked immunosorbent assay(ELISA).The gene expression of IL-4 receptor(IL-4R) in lung of IPF rats was detected by Real-time PCR.The protein content of signal transducer and activator of transcription6(STAT6) was detected by Western Blot.Reaults:IL-4 content in the serum of IPF rats was down regulated through treated by Bushen Yifei Xiaozheng Formula and increased the gene expression of IL-4R(P0.01,P0.05).Conclusion:This formula should release the inflammatory reaction and inhibit the process of pulmonary fibrosis through down regulated the IL-4 content and interfering the gene expression of key molecules in IL-4 signal pathway.This should be the key site in mechanism of action." @default.
- W2369098587 created "2016-06-24" @default.
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- W2369098587 date "2013-01-01" @default.
- W2369098587 modified "2023-09-23" @default.
- W2369098587 title "Influences of Bushen Yifei Xiaozheng Formula on expression of key molecules in IL-4 signal pathway of IPF rat" @default.
- W2369098587 hasPublicationYear "2013" @default.
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