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- W2369116228 abstract "Objective To optimize the preparation method of levodopa(LD) ethylcellulose(EC) microcapsules.Method LD was microcapsulated by the method of intra-liquid desiccation.The index of drug-loading rate and entrapment rate were selected as indexes,and the preparing of LD microcapsules was optimized by the orthogonal design.Results The optimized preparing way of LD microcapsules was as follows:the weight rate of EC and LD was 0.6∶1.4,the rate of oil phase and water phase was 105∶30 and the weight of PVP was 0.2 g.The result of verification test showed that the drug-loading rate of optimized LD microcapsules was 54.94% and the entrapment rate was 89.2%.The results of quality inspection showed that the appearance of LD microcapsules was rounding and kept from sticking.The range of particle size of LD microcapsules was 300-600 μm.Microcapsules release in vitro had a sustained release characteristics.Conclusion The preparation method of LD is stable and reliable.The condition of preparation is reasonable and feasible." @default.
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- W2369116228 date "2011-01-01" @default.
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- W2369116228 title "Study on the preparation of Levodopa Microcapsules" @default.
- W2369116228 hasPublicationYear "2011" @default.
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