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- W2369130320 abstract "Hepatic fibrosis is a common pathophysiological change in clinic,its genesis and development is a dynamic process,now the reversibility of liver fibrosis is clear.With the continuous development of evidence-based medicine and modern biotechnology,the mechanism of cytokines that against the process of liver fibrosis has also been gradually clari fied.Now it is clear that the activation of hepatic stellate cells(HSC) and the continuous generations and degradations of the extracellular matrix determine the outcome of liver fibrosis.Among the anti-fibrotic cytokines,matrix metalloproteinase family plays a vital role in the extracellular matrix degradation.Interleukin-10 can not only down-regulate the expression of TGF-β1 and EGF cytokines,thereby reducing the HSC cell activation and proliferation,but also stimulate the synthesis of matrix metalloproteinases that leads to increase the extracellular matrix degradations.This article summarizes the char acteristics of matrix metalloproteinases and interleukin-10,and their role in the process of anti-fibrotic." @default.
- W2369130320 created "2016-06-24" @default.
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- W2369130320 date "2012-01-01" @default.
- W2369130320 modified "2023-09-23" @default.
- W2369130320 title "Mechanism of MMPs and IL-10 factor in the resistance of liver fibrosis" @default.
- W2369130320 hasPublicationYear "2012" @default.
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