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- W2369138839 abstract "AIM: To determine the inhibitory effects of methotrexate (MTX) and tripterygium glycosides (TG) on chemokine CCL5 production in synoviocytes isolated from patients with rheumatoid arthritis (RA). METHODS: Synoviocytes, isolated from 13 RA patients and 7 patients with osteoarthritis (OA), were cultured and stimulated with or without lipopolysaccharide (LPS) in the presence or absence of different dosages of MTX or TG. CCL5 level in culture supernatants was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: RA synoviocytes spontaneously produced a higher level of CCL5 than OA synoviocytes did(P0.05). Both MTX and TG were found to significantly inhibit LPS-induced CCL5 production in RA synoviocytes(both P0.001), while no significant difference was found between the two (P0.05). Moreover, the inhibitory effect of MTX appeared to be in a dosage dependent manner at the concentration ranging from 5-20 μg/L, whereas, TG showed its inhibitory effect only when its concentration reached 40 μg/L . Furthermore, the inhibitory effect of TG was found to be correlated with TG-induced cell death. CONCLUSION: The increased production of CCL5 by RA synoviocytes indicates a role of CCL5 in the pathogenesis of RA, and the modifying roles of MTX and TG for the disease might exist through their anti-CCL5 effect and the inhibitory effect of TG is associated with its cytotoxic action." @default.
- W2369138839 created "2016-06-24" @default.
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- W2369138839 date "2006-01-01" @default.
- W2369138839 modified "2023-09-28" @default.
- W2369138839 title "Inhibitory effects of methotrexate and tripterygium glycosides on chemokine CCL5 production in synoviocytes from patients with rheumatoid arthritis" @default.
- W2369138839 hasPublicationYear "2006" @default.
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