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- W2369143075 abstract "OBJECTIVE:To compare the efficacy and toxicity of etoposide plus cisplation(EP) regiment,irinotecan plus cisplation(IP) regiment and topotecan plus cisplation(TP) regiment in first-line treatment of small cell lung cancer(SCLC).METHODS:Totally 81 patients of SCLC were divided equally by digital random table method,and treated with EP regiment,IP regiment and TP regiment.All patients were given more than three chemotherapy cycles.The therapeutic effect and toxicity were evaluated after the treatment.RESULTS: The overall response rates(RR) were 66.67%(18/27),74.07%(20/27) and 62.96%(17/27).There were no significant differences among the three groups(EP vs IP,χ2=0.089,P=0.766;EP vs TP,χ2=0.000,P=1.000;IP vs TP,χ2=0.343,P=0.559).The disease control rates(DCR) were 88.89%(24/27),88.89%(24/27) and 85.19%(23/27).There were no significant differences for the three groups(χ2=0.000,P=1.000).Ⅲ-Ⅳgrade leucopenia for that of TP regimen was higher than IP regimen(χ2=5.494,P=0.018).Ⅲ-Ⅳgrade thrombocytopenia for TP regimen was higher than that of EP regimen(χ2=3.668,P=0.050).Ⅲ-Ⅳgrade tardily diarrhea for IP regimen was higher than that for the other two groups(χ2=4.688,P=0.023).CONCLUSIONS: IP regimen and TP regimen in the first-line treatment of SCLC have good clinical efficancy.IP regiment has higher diarrhea incidence and TP regiment has higher hematological toxicities,and these side effects are tolerable by symptomatic treatment." @default.
- W2369143075 created "2016-06-24" @default.
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- W2369143075 date "2013-01-01" @default.
- W2369143075 modified "2023-09-23" @default.
- W2369143075 title "Cisplation combined with etoposide irinotecan and topotecan respectively forpatients with small cell lung cancer as first-line treatment" @default.
- W2369143075 hasPublicationYear "2013" @default.
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