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- W2369151325 abstract "Objective To investigate the impact of hypothermia on the function of heart,liver and kidney in the neonates with hypoxic-ischemic encephalopathy(HIE).Methods Twenty-two neonates with HIE were randomly divided into two groups,i.e.TH group treated with hypothermia(n=12) and normothermia control group(n=10).Hypothermia(33-34℃) was maintained in HT group for 72h after birth.Normothermia was maintained for 72h in control group.Serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),MB isoenzyme of creatine kinase(CK-MB),uric acid(UA) and urine creatinine(Ucr) levels were examined at 6h,24h,48h,72h after birth.Results The values of ALT and CK-MB in HT group at 24h were lower than those in control group(P0.05 or P0.01).The values of ALT,CK-MB and UA in HT group at 48h were lower than those in control group(P0.05 or P0.01).The values of ALT,AST,LDH,CK-MB and UA in HT group at 72h were lower than those in control group.Three of the HT group and six of the control group developed to multiorgan dysfunction(MODS),with significant difference in incidence rate between the two groups(P0.05).Conclusion Systemic hypothermia may protect the function of important organs and prevent the injury of multiple organs in neonatal asphyxia." @default.
- W2369151325 created "2016-06-24" @default.
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- W2369151325 date "2008-01-01" @default.
- W2369151325 modified "2023-09-24" @default.
- W2369151325 title "Effect of Systemic Mild Hypothermia Therapy on Neonates with Hypoxic-ischaemic Encephalopathy" @default.
- W2369151325 hasPublicationYear "2008" @default.
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