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- W2369170051 abstract "Objective: To explore the inhibitory effect of nanosilver(Nano-Ag) on herpes simplex virus-1(HSV-1).Methods: The MTT analysis method,the cytopathic effect(CPE) test,the transmission electron microscopy(TEM) and flow cytometry were used to determine the effects of Nano-Ag on HSV-1.Results: The maximal non-toxic concentration(TD0) of Nano-Ag was 50μg·mL-1,and the 50% tissue culture infectious dose(TCID50) of HSV-1 was 10-4.5·100μL-1 in HeLa cells.Cell survival and apoptosis rates of HeLa cells were(101.48±2.29)% and(8.47±1.96)%,respectively.The CPE was negative and cell morphology was normal(by electron microscopy) after HeLa cells were infected by 400 TCID50 of HSV-1 that was mixed with 100μg·mL-1 Nano-Ag(2h at room temperature).The survival and the apoptosis rates of HeLa cells were(17.13±2.20)% and(25.72±1.37)%,respectively;the CPE was positive(++++,P0.001) after HeLa cells were infected by 200TCID50 of HSV-1.Conclusion: Nano-Ag exerts remarkable inhibitory effect on HSV-1." @default.
- W2369170051 created "2016-06-24" @default.
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- W2369170051 date "2010-01-01" @default.
- W2369170051 modified "2023-09-26" @default.
- W2369170051 title "Inhibitory effect of nanosilver on herpes simplex virus" @default.
- W2369170051 hasPublicationYear "2010" @default.
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