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- W2369173882 abstract "Objective To research the effect of lipotoxicity on pancreatic islet β cell apoptosis and its mechanism. Methods T2DM model in Sprague-Dawley rats was established by high fat feeding followed by low dose STZ injection. Then the apoptotic β cells were checked,and the serum data of metabolism were compared between groups. Results The rat model was similar to the general type 2 diabetes. In model group, triglyceride,cholesterol and fasting serum glucose and β cell apoptosis were higher than those in other groups. The rate of β cell apoptosis was positively correlated with serum glucose. Conclusions Lipotoxicity advances the β cell apoptosis, impairs the β cell function and may induce the development of type 2 diabetes." @default.
- W2369173882 created "2016-06-24" @default.
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- W2369173882 date "2009-01-01" @default.
- W2369173882 modified "2023-09-25" @default.
- W2369173882 title "The study on the relationship of lipotoxicity and the apoptosis of pancreatic islet β-cell in rats with type 2 diabetes" @default.
- W2369173882 hasPublicationYear "2009" @default.
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