Matches in SemOpenAlex for { <https://semopenalex.org/work/W2369183795> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2369183795 abstract "OBJECTIVE: To study the inhibitory effect of sodium norcantharidin lipid microsphere injection on nude mice bearing human carcinoma A549. METHODS:Animal model of human lung cancer was established by inoculating human carcinoma A549 cells to BALB/c nude mice. 11 days after inoculation,mice were randomly divided into control group,positive control group,and other three groups with different doses of sodium norcantharidin lipid microsphere injection. The mice received physiological saline,2.5 mg/kg sodium norcantharidin injection,and 1.25,2.5 or 5 mg/kg sodium norcantharidin lipid microsphere injection at 1 d,4 d,8 d,11 d,15 d,18 d,and 22 d after grouping. The tumor volume(Vt),relative volume(VR T),and the increment rate(T/C) were measured at 7 d,14 d,and 24 d after the first injection. The weight of tumors and the growth inhibition rate in vivo were measured at 24 d after the first injection. RESULTS:The tumor volume and the relative volume of all treated groups were much smaller than the group with negative control 7 days after the first injection,and the difference was significant(P0.05). These effects showed drug dose- effect relationships(r7 d =0.994,r1 4 d =0.993,r 24 d =0.996). The tumor increment rate of all treated groups were lower than 25%,especially the medium dose and the high dose groups which dropped to below 20%. The average tumor weights of the treated groups were lower than the control group(P0.01). The growth inhibition rates were more than 50%. CONCLUSION:Sodium norcantharidin lipid microsphere injection effectively inhibited the growth and reduced increment rate of human carcinoma A549 transplanted in nude mice." @default.
- W2369183795 created "2016-06-24" @default.
- W2369183795 creator A5075435961 @default.
- W2369183795 date "2015-01-01" @default.
- W2369183795 modified "2023-09-23" @default.
- W2369183795 title "Inhibitory effect of sodium norcantharidin lipid microsphere injection on nude mice bearing human carcinoma A549" @default.
- W2369183795 hasPublicationYear "2015" @default.
- W2369183795 type Work @default.
- W2369183795 sameAs 2369183795 @default.
- W2369183795 citedByCount "0" @default.
- W2369183795 crossrefType "journal-article" @default.
- W2369183795 hasAuthorship W2369183795A5075435961 @default.
- W2369183795 hasConcept C126322002 @default.
- W2369183795 hasConcept C134018914 @default.
- W2369183795 hasConcept C150903083 @default.
- W2369183795 hasConcept C185592680 @default.
- W2369183795 hasConcept C207001950 @default.
- W2369183795 hasConcept C2776256026 @default.
- W2369183795 hasConcept C2777397205 @default.
- W2369183795 hasConcept C2777546739 @default.
- W2369183795 hasConcept C71924100 @default.
- W2369183795 hasConcept C81729549 @default.
- W2369183795 hasConcept C86803240 @default.
- W2369183795 hasConcept C98274493 @default.
- W2369183795 hasConceptScore W2369183795C126322002 @default.
- W2369183795 hasConceptScore W2369183795C134018914 @default.
- W2369183795 hasConceptScore W2369183795C150903083 @default.
- W2369183795 hasConceptScore W2369183795C185592680 @default.
- W2369183795 hasConceptScore W2369183795C207001950 @default.
- W2369183795 hasConceptScore W2369183795C2776256026 @default.
- W2369183795 hasConceptScore W2369183795C2777397205 @default.
- W2369183795 hasConceptScore W2369183795C2777546739 @default.
- W2369183795 hasConceptScore W2369183795C71924100 @default.
- W2369183795 hasConceptScore W2369183795C81729549 @default.
- W2369183795 hasConceptScore W2369183795C86803240 @default.
- W2369183795 hasConceptScore W2369183795C98274493 @default.
- W2369183795 hasLocation W23691837951 @default.
- W2369183795 hasOpenAccess W2369183795 @default.
- W2369183795 hasPrimaryLocation W23691837951 @default.
- W2369183795 hasRelatedWork W2008187359 @default.
- W2369183795 hasRelatedWork W2060063916 @default.
- W2369183795 hasRelatedWork W2354189070 @default.
- W2369183795 hasRelatedWork W2359107428 @default.
- W2369183795 hasRelatedWork W2362923964 @default.
- W2369183795 hasRelatedWork W2366271449 @default.
- W2369183795 hasRelatedWork W2366437368 @default.
- W2369183795 hasRelatedWork W2369071974 @default.
- W2369183795 hasRelatedWork W2372472785 @default.
- W2369183795 hasRelatedWork W2377225125 @default.
- W2369183795 hasRelatedWork W2380807696 @default.
- W2369183795 hasRelatedWork W2381325625 @default.
- W2369183795 hasRelatedWork W2384120296 @default.
- W2369183795 hasRelatedWork W2385410762 @default.
- W2369183795 hasRelatedWork W2388762021 @default.
- W2369183795 hasRelatedWork W2390044649 @default.
- W2369183795 hasRelatedWork W2390675486 @default.
- W2369183795 hasRelatedWork W2392685597 @default.
- W2369183795 hasRelatedWork W2597718923 @default.
- W2369183795 hasRelatedWork W3032413159 @default.
- W2369183795 isParatext "false" @default.
- W2369183795 isRetracted "false" @default.
- W2369183795 magId "2369183795" @default.
- W2369183795 workType "article" @default.