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- W2369202273 abstract "Aim To explore the effect of oxidized low density lipoprotein(ox-LDL) on human vascular umbilical vein endothelial cell(HUVEC) autophagy and its mechanism.Methods After treatment with ox-LDL for 24 h,Western blot was used to detect the protein expression of Beclin-1 and microtubule-associated protein 1 light chain 3(LC3);Reverse transcription polymerase chain reaction(RT-PCR) and Western blot were used to detect Rab4 mRNA and protein expression.After transfection with Rab4 siRNA and Rab4 plasmid,Western blot was used to measure the protein levels of Rab4,Beclin-1 and LC3 induced by 75 mg/L ox-LDL.Results After treatment with ox-LDL for 24 h,the protein expression of Beclin-1 and the ratio of LC3Ⅱ/LC3Ⅰ were increased.The levels of Rab4 mRNA and protein were obviously decreased with a concentration-dependent manner.When transfection with Rab4 siRNA,the protein level of Beclin-1 and the ratio of LC3Ⅱ/LC3Ⅰ induced by ox-LDL were further increased.When transfection with Rab4 plasmid,the increased protein level of Beclin-1 and the ratio of LC3Ⅱ/LC3Ⅰ induced by ox-LDL were attenuated.Conclusion ox-LDL increased HUVEC autophagy via down-regulation of Rab4 expression." @default.
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- W2369202273 date "2013-01-01" @default.
- W2369202273 modified "2023-09-25" @default.
- W2369202273 title "Oxidized Low Density Lipoprotein Induces Human Vascular Umbilical Vein Endothelial Cells Autophagy via Down-regulation of Rab4 Expression" @default.
- W2369202273 hasPublicationYear "2013" @default.
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