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- W2369211595 abstract "Objective To investigate the expressions of leptin and adiponectin in human stellate cell strain LX 2 after treated with curcumin,and to explore the roles of leptin and adiponectin in anti-hepatic fibrosis of curcumin.Methods LX-2 cells were cultivated in vitro with curcumin(0,10,20,30,40,50,60,70 and 80 μmol/L).The cell proliferation was detected by MTT.According to the results of proliferation,30,40 and 50 μmol/L curcumin were adopted to treat LX-2 for 24 h.Expression of leptin and adiponectin in LX-2 was assessed by immunochemistry.Results Significant inhibition of the cell proliferation was observed after treatment of curcumin over 30 μmol/L(P0.05).Significant down-regulation of leptin and up-regulation of adiponectin were revealed after treatment of curcumin in a dose-dependent manner(P0.05).Conclusion Curcumin could down-regulate leptin while boost adiponection in LX-2,thus inhibits HSC proliferation." @default.
- W2369211595 created "2016-06-24" @default.
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- W2369211595 date "2013-01-01" @default.
- W2369211595 modified "2023-09-24" @default.
- W2369211595 title "Effects of curcumin on the expressions of leptin and adiponectin in human stellate cell strain LX-2" @default.
- W2369211595 hasPublicationYear "2013" @default.
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