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- W2369228035 abstract "OBJECTIVE: To evaluate the changes of some risk factors for lacunainfarction(LI)in non-diabetic essential hypertension(EH) patients before and afterthe administration of ACEI, cilazaepril., METHOD:fifty-three patients with LI andEH.(M:32,F:2l;Age:55±7),divided into two groups:treatment with ACEI, cilazaepril(c), 25-5mg.d-1, (Average:3.0mg.d-1)(n=36) andβ-blocker, metopronolol(M),25~100mg.d-1(Average:42.6mg.d-1)(n=17),follewed for eight to eighteen months(Average:sixteen months). Quantification of LI in MRI with computer; Cedeholminsulin sensitivity index (ISIc) calculated from the results of oral glucose tolerancetest(OGTT) and insulin release test(inRT); lipid (Tc,Tg,LDL-c,HDL-c); serum uricacid(UA);PAI-l;tPA and urinary microalbumin were studied before and aftermedication.RESULTS:(l)According to the results from OGTT, fifty-three patientswere divided in to two groups: IGT(n=l5) and NGT (n=38)groups.In which ISIc andquantification of LI were 39.l±7.9, 6l.2±2l.l min-1.mu.L-1(P005) and l54.6±ll6.4mm2, 88.5±80.8mm2(P0.05),respectively(2)Comparing the treatment groups of C(n=36) with M(n=l7) some risk factors:ISIc in C groups significantly improved than in M groups(P0.05); the incidents ofdiabetic were 8.3%(3/36) and 29.4%(5/l7)respectively; Tg,LDL-c,UA and PAI-l significantly decreased in C groups but Tg, Tc, LDL-c UA significantly decreased in Mgroup.CONCLUSION: ACEI, cilazaepril seems to improve some risk factors of LI with EH, including lipid metabolism, uric acid,PAI-l,ISIc,besides lower blood pressure.In the meantime, lower incidence of diabetic was found in cilazaepril than inmetopromolol group.It suggest that ACEI,cilazaepril could protect micro-cerebral vessel in EH patients." @default.
- W2369228035 created "2016-06-24" @default.
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- W2369228035 date "2002-01-01" @default.
- W2369228035 modified "2023-09-25" @default.
- W2369228035 title "Cilazaepril,Reverse Some Risk Factor for Lacuna Infarction Patients with EssentialHypertension" @default.
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