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- W2369229265 abstract "Objective To investigate the expression of CD147 and P53 and their clinical significance in HCC.Methods The expression of CD147 and P53 was determined by tissue microarray and immunohistochemistry(IHC)in 272 cases of HCC.Results The positive expression of CD147 were closely correlated to the histological grade,the TNM clinical stage,the survival months with no tumor after operation,the diameter of tumor and the embolus of cancer in aqueduct or portal vein,but not to the other marker(P0.05).The expression of P53 in HCC were closely correlated to the survival months with no tumor after operation,the histological grade,the involucrum invasion in liver,the quantity of AFP in blood and lymph node metastasis,but not to other marker(P0.05).Among the patients of positive expression of CD147,their middle replasing months and middle survival months were shorter and had closely correlation(χ2=41.507,P=0.000;χ2=36.636,P=0.000)compared with the patients of negative expression.And among the patients of positive expression of P53,their middle replasing months and middle survival months were shorter and have closely correlation(χ2=10.046,P=0.002;χ2=10.279,P=0.001)compared with the patients of negative expression.The expression of CD147 had no correlation with the expression of P53(r=0.007,P=0.914).Conclusion The positive expression of CD147 and P53 closely correlate with the clinical prognosis of HCC and a poor prognisis of HCC probably." @default.
- W2369229265 created "2016-06-24" @default.
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- W2369229265 date "2012-01-01" @default.
- W2369229265 modified "2023-09-23" @default.
- W2369229265 title "Expression and clinical significance of CD147 and P53 in Hepatocellular carcinoma(HCC)" @default.
- W2369229265 hasPublicationYear "2012" @default.
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