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- W2369279968 abstract "Objective To evaluate the efficacy of FEV6 and FEV1/FEV6 as surrogates for FVC and FEV1/FVC in the spirometric diagnosis of airway obstruction,and to determine the fixed cut-off point of FEV1/FEV6 which can be used as an alternative for FEV1/FVC70%.Methods Spirometry measurements were performed in 128 participants.FEV1,FEV6,FVC,FEV1%pred,FVC%pred,FEV1/FVC and FEV1/FEV6 were measured and analyzed.FEV1/FVC70% was used as the gold standard.Severity of obstruction was based on FEV1%pred.From ROC curve analysis,the FEV1/FEV6 ratio,which corresponded to optimal combination of sensitivity and specificity,was determined.Correlation between FEV1/FVC and FEV1/FEV6 was studied.Results Of 128 participants,there were 65(51%) with FEV1/FVC ≥70%.Of the 63 participants with FEV1/FVC70%,there were 5 with FEV1/FEV6 between 70.09% to 71%.There was no significant difference between the mean value of FVC and that of FEV6.Linear correlation was revealed between FEV1/FVC and FEV1/FEV6 with the value close to 1(r=0.9979,P0.0001).From ROC curve analysis,the FEV1/FEV671.14% was the best cut-off point corresponding to FEV1/FVC70%.Conclusion These results suggest that FEV1/FEV6 is a valid alternative to FEV1/FVC for spirometric diagnosis of airway obstruction.There is a strong correlation between FEV1/FEV6 and FEV1/FVC." @default.
- W2369279968 created "2016-06-24" @default.
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- W2369279968 date "2008-01-01" @default.
- W2369279968 modified "2023-09-27" @default.
- W2369279968 title "Forced expiratory volume in six seconds in the spirometric diagnosis of airway obstruction" @default.
- W2369279968 hasPublicationYear "2008" @default.
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