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- W2369280065 abstract "Objective To explore the effect and mechanism of telmisartan on the level of advanced glycation endproducts(AGEs)and receptor for advanced glycation end products(RAGE)in spontaneously hypertensive rats(SHR).Methods Twenty-four 22-week-old SHR were randomly divided into control group(HC group)and telmisartan group(T group),and there were 12SHR in each group.Thirteen same-age Wistar Kyoto rats were as a natural control group(NC group).T group was fed telmisartan 6mg/(kg·d).Systolic blood pressure(SBP)of rats tail was measured every two weeks.After 16weeks of intervention,we detected the level of NO,superoxide dismutase(SOD),AGEs in Abdominal aorta serum RAGE mRNA expression levels in abdominal aorta tissue.Results Compared with NC group,the level of SBP in HC group was significantly higher(P0.01).Compared with the HC group,the level of SBP in HC group was significantly decreased(P0.01).Compared with NC group,NO value of HC group was lower(P0.05),SOD value of HC group was lower(P0.01),AGEs value of HC group was higher(P0.01),and RAGE mRNA correction of HC group was higher(P0.01).Compared with the HC group,the value of NO,SOD were higher(P0.05),AGEs was significantly lower(P0.01),the level of RAGE mRNA was lower(P0.05)in T group.Conclusion Telmisartan may reduce the level of AGEs and RAGE mRNA in SHR through oxidative stress." @default.
- W2369280065 created "2016-06-24" @default.
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- W2369280065 date "2013-01-01" @default.
- W2369280065 modified "2023-09-23" @default.
- W2369280065 title "Effect and mechanism of telmisartan on the level of AGEs-RAGE in spontaneously hypertensive rats" @default.
- W2369280065 hasPublicationYear "2013" @default.
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