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- W2369283669 abstract "Objective: To investigate the expressions of High Mobility Group Box 1(HMGB1) and matrix metalloproteinase-9(MMP-9) in human cervical squamous epithelial carcinoma(CSEC),and to explore the relationship among HMGB1,MMP-9 and clinical pathological characteristics of CSEC.Methods: Immunohistochemisty methods were adopted to detect the expressions of HMGB1 and MMP-9 in cervical squamous epithelial infiltrating carcinoma(CSEIC),carcinoma in situ(CIS) and normal control groups.Results: The positive expression rate of HMGB1 in CSEIC,CIS and control group was 80.0%(32/40),53.3%(8/15) and 15.8%(3/19),respectively,with a significant difference among them(P0.01).The expression of HMGB1 had no relation with age,differentiation degree,lymphatic metastasis or clinical classification(all P0.05).The positive expression rate of MMP-9 in CSEIC,CIS and control group was 65.0%(26/40),53.3%(8/15) and 21.5%(4/19),respectively(P0.01).There is a positive correlation between the expression of HMGB1 and MMP-9 in CSEC,and their co-positive rate was 47.3%(26/55,rs=0.305,P0.05).Conclusion: HMGB1 plays a role in the development of CSEC.The expressions of HMGB1 and MMP-9 in CSEC have a positive correlation with each other,which suggests that HMGB1 might be related with the invasive and metastasis of cervical carcinoma." @default.
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- W2369283669 date "2010-01-01" @default.
- W2369283669 modified "2023-09-25" @default.
- W2369283669 title "Expressions of High Mobibity Group Box 1 Protein and Matrix Metalloproteinase-9 in Cervical Squamous Epithelial Carcinoma and Their Clinical Significance" @default.
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