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- W2369312544 abstract "Objective: To evaluate the pathological and morphologic changes and effects on liver function after percutaneous hot saline injection (PSIT) in dog liver. Methods: Hot saline with 2 to 12 ml was injected into dog liver specimen, and the relationship between its dosage and the size of coagulative necrosis was observed. In addition, 15ml of hot saline was injected into 14 dog livers in vivo,the animals were followed up for 1 - 45 days with liver function test,CT,MRI,gross and microscopic examinations. Results:The size of coagulative lesion became larger with increasing dosage of hot saline injected at the range of 2 - 12 ml,but there was obvious fluid reflux when dosage of saline injected was above 10ml. There was no significant elevation of ALT, AST,GGT and ALP level after the procedure(PX). 05). Pathologically,three zones(the central zone,coagulated zone and congestive,haemorrhagic zone) could be distinguished in the area of coagulation. Large vessels and bile ducts contiguous to the lesions were intact. The treated area showed decreased density on unenhanced CT,and no enhancement on contrast-enhanced CT. Peripheral enhancement rim could be seen in all lesions after PSIT. The treated area demonstrated a low intensity area on T1WI,and a high intensity area on T2WI. The treated areas were devoid of gadolinium enhancement,and a peripheral enhancement rim also could be seen. Conclusion:Coagulation necrosis of the liver tissue can be induced by hot saline injection. PSIT is a safe treatment modality. CT and MR appearances of the treated area after PSIT closely correlate with pathological findings." @default.
- W2369312544 created "2016-06-24" @default.
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- W2369312544 date "2002-01-01" @default.
- W2369312544 modified "2023-09-24" @default.
- W2369312544 title "Percutaneous transhepatic hot saline injection therapy: an experimental study" @default.
- W2369312544 hasPublicationYear "2002" @default.
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