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- W2369316094 abstract "Objective:To investigate the effects and the mechanism of ligustrazine on nitroglycerin (NTG) resistance.Method:60 cases of unstable angina patients were allocated to three groups:NTG group(Group Ⅰ),TNG plus captopril group (Group Ⅱ),and NTG plus ligustrazine group(Group Ⅲ).NTG was administrated by intravenous drip for 24 hours,captopril 12.5 mg was administrated orally and ligustrazine 1.6mg/kg by intravenous drip.The percentage of NTG resistance,systolic blood pressure(SBP),and the level of plasma lipid peroxide (LPO),surperoxide dismutase(SOD),nitric oxide (NO),endothelin(ET) and angiotension Ⅱ(Agn Ⅱ)were investigated.Results:(1)the percentage of NTG resistance in Group Ⅱ and Group Ⅲ were lower than that in Group Ⅰ(P0.05);(2)plasma nitric oxide serves as an indicator of NTG resistance;(3)Ligustrazine and captopril exert similar effects in counteracting NTG resistance.Conclusion:Inhibition of oxygen free radicals system may be the mechanism of ligustrazine in counteracting NTG resistance." @default.
- W2369316094 created "2016-06-24" @default.
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- W2369316094 date "2000-01-01" @default.
- W2369316094 modified "2023-09-25" @default.
- W2369316094 title "Effects of Ligustrazine on Nitroglycerin-Resistance" @default.
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