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- W2369322812 abstract "To analyze gene sequence and predict the B cell epitopesof Chlamydia trachomatis(Ct) polymorphic membrane protein D(PmpD).Search the gene sequences of the different Ctserotypes in GenBank,and then align them by LaserGene software.The secondary structure and the flexibility plot of PmpD of Ct serovar L2 were predicted by the algorithmof Karplus-Schulz,Chou-Fasman and Gamier-Robson based on PmpD sequence,and the antigenic index,the hydrophilicity plot and the surface probability plot were predicted by the methods of Jamesonv-Wolf,Kyte-Doolittle and Emini respectively.Sequence alignments indicate that the PmpDgenes of the 20 different Ctstrains share 99.14-100% identical nucleotide sequences.The B cell epitopes of PmpD by these predicted results was analyzed,which are most likely localized in or adjacent to its N-terminal No.67-74,132-140,335-340,851-861,972-988,1091-1097 of PmpD.The results obtained by epitopes prediction using multiple parameters are helpful for further epitopes identification and design of multiepitopes-based vaccine of PmpD." @default.
- W2369322812 created "2016-06-24" @default.
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- W2369322812 date "2008-01-01" @default.
- W2369322812 modified "2023-09-26" @default.
- W2369322812 title "Sequence analyses of Chlamydia trachomatis polymorphic membrane protein D gene and prediction of related B cell epitopes" @default.
- W2369322812 hasPublicationYear "2008" @default.
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