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- W2369331567 abstract "Objective: To systematically evaluate combinative efficacy of Fuzheng Huayu capsule with nucleotide analogues in treating liver fibrosis due to chronic hepatitis B based on randomized controlled trials(RCTs).Methods: Retrieval strategy RCT reports published until June 2012 were retrieved from databases,including SinoMed,CNKI,Wanfang database system,OVID,Springer and manually.Participants received treatments of Fuzheng Huayu capsule with nucleotide analogues were pooled into trial group,while nucleotide analogues monotherapy were into control group.Two reviewers screened the RCTs independently,extracted the information and cross-checked them.Jadad scale and the Cochrane risk of bias tool were used to assess the study quality of the included RCTs and the statistical software RevMan 5.1 was used for data analysis.Results: Eight RCTs with 608 participants were included.One of the reports was scored 2 and the others was 1 evaluated by the Jadad scale.Compared to con-trol group,there was a significant decease in serologic markers of liver fibrosis such as HA,laminin,P-Ⅲ-P and collagen Ⅳ in trial group.As for serum liver functions,greater improvement of serum ALT,AST and albumin was shown in trial group than that of control group.Trial group demonstrated a better efficacy in decreasing spleen thickness than control group.But there was no significant difference between the trial and control group in negative conversion rate of HBV DNA and HBeAg.Conclusion: This meta-analysis confirms that Fuzheng Huayu capsule with nucleotide analogues has better efficacy on alleviating serological markers of liver fibrosis and improving liver functions than nucleotide analogues monotherapy in patients with liver fibrosis or cirrhosis due to chronic hepatitis B.But the reliable efficacy should be confirmed by strict RCTs which use histologic pathology as the primary evaluation criteria." @default.
- W2369331567 created "2016-06-24" @default.
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- W2369331567 date "2013-01-01" @default.
- W2369331567 modified "2023-09-25" @default.
- W2369331567 title "A systematic review of combinative effects of Fuzheng Huayu capsule with nucleotide analogues on liver fibrosis due to chronic hepatitis B" @default.
- W2369331567 hasPublicationYear "2013" @default.
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