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• W2369334933 abstract "AIM The present study was designed to observed wether oral losartan would protect vascular endothelial cells in atherosclerotic aorta in rabbit induced by cholesterol diet. METHODS Fifty long ear Janpan white rabbits were randomly divided into five groups. Group E were fed standard diet, group A were fed choleterol diet, and group B, C and D were fed cholesterol diet and simultaneously received 10 mg·kg -1 ·d -1 ,25 mg·kg -1 ·d -1 of losartan and 10 mg·kg -1 ·d -1 of captopril respectively for 12 weeks. At the end of experiment, the rabbit blood samples were collected for measurement of the lipid profile. The rabbits were killed after dietary intervetion. The blood vessels was isolated from aorta to iliac artery, and adjacent to aortic arch were harvested for tissue review. While the thoracic aorta were cut into 4mm rings and mounted in organ bath for measurement of isometric force development. Dose response curve to acetylcholine, nitroglycerine, and noradrenaline were constructed. The rest tissue of made into tissue homogenate was used for measurement of the concentration of AngⅡ and ET 1. RESULTS ①The total lipid level in blood and AngⅡ level in tissue were significantly elevated in the rabbits fed cholesterol diet compared with that in groups E. The ET 1 level in tissue was significiantly elevated in group A and D compared with that in group B, C, and E( P 0 01). ② Endothelium dependent relaxation to acetylcholine and no endothe liumdependent relaxation to nitroglycerine were sinificiantly impaired in thoracic aorta rings in group A( P 0 01), but there no significiant difference in group B, C and D, compared with that in group E ( P 0 05). The constructive response to noradrenaline was significantly increased in group A and B, compared with that in group E ( P 0 01). However, these response in group C and D was similar to that in group E. ③ The media area was similar in each experimental group. The vessel area in group A, B, C, and D were enhanced significantly compared with that in group E ( P 0 05), the intima thick was enhanced and the lumen area was decreased significantly in group A compared with that in group E after intervention of the drugs, although the intima thick was significantly increased in group B, C, and D compared with that in group E, the lumen area were enhanced significantly compared with that in group A ( P 0 01). CONCLUSION In hypercholesterolmia, the concentration of AngⅡ in vessel tissues was increased significantly, and it maybe induced the vascular remodling and endothelial dysfunction via AT 1 receptor. AngⅡ type Ⅰreceptor antagonist, losartan has the protective effect on vascular endothelial cells and so delay the development of the atherosclerosis." @default.
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• W2369334933 date "2003-01-01" @default.
• W2369334933 modified "2023-09-27" @default.
• W2369334933 title "The protective effect of losartan on vascular endothelial cells for experimental atherosclerosis in rabbits" @default.
• W2369334933 hasPublicationYear "2003" @default.
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