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- W2369340008 abstract "Objective To study the effect of Danshen on the pharmacokinetics of Rosuvastatin in rats.Methods Parallel control method was applied in this study.Twelve male rats weighing(230±15) g were evenly randomized into two groups: rosuvastatin(80 mg/kg) group and Rosuvastatin plus Danshen(400 mg/kg) group.Blood samples(0.3 ml each) were collected from the orbital vein at 0.5,1,1.5,3,5,8,10,12 and 24 h after drug administration.LC-MS was used to determine the plasma concentrations of Rosuvastatin.The pharmacokinetic parameters of the two groups were compared and statistical analysis was performed using SPSS12.0 software.Results When combined with Danshen,the Cmax,AUC0-t,and AUC0-∞ of Rosuvastatin were increased by 60.81%,88.00% and 82.92%,and T1/2 and CLz/F were reduced by 33.21% and 21.51%,respectively.Conclusion Danshen can affect the pharmacokinetic properties of Rosuvastatin in rats." @default.
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- W2369340008 date "2012-01-01" @default.
- W2369340008 modified "2023-09-23" @default.
- W2369340008 title "Effect of Danshen on pharmacokinetics of Rosuvastatin in rats" @default.
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