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- W2369351902 abstract "Aim To investigate whether d-α-tocopherol supplementation had protective effect on the pro-oxidant-antioxidant state following chronic ethanol treatment in mouse liver and its underlying mechanism.Methods Mice were randomly divided into 5 groups:control(NC),ethanol control(EC),d-α-tocopherol 1(TOC 1),d-α-tocopherol 2(TOC 2)and d-α-tocopherol 3(TOC 3)group.After ingesting ethanol(2.4 g ethanol·kg-1 bw),the mice were treated by d-α-tocopherol(25,50,100 mg·kg-1 bw·d-1,respectively),meanwhile,the normal control group and ethanol control group(2.4 g ethanol·kg-1 bw)were set up.The activities of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),ATPase and glutathione-S transferase(GST)in liver were measured,meanwhile the concentration of malondialdehyde(MDA)was determined when the mice were continuously treated for 60 d.Results There was significant change in all indices between the ethanol control group and normal control group(P0.05)except Ca2+,Mg2+-ATPase.The supplement of 50 mg·kg-1 bw·d-1 d-α-tocopherol could significantly prohibit the rise of MDA level and the decline of GSH-Px,SOD,Na+,K+-ATPase and GST activity induced by chronic alcohol intakes.The activity of Na+,K+-ATPase and GSH-Px were ameliorated by 25 mg·kg-1 bw·d-1 d-α-tocopherol,meanwhile,the rise of MDA level in liver was prohibited.Conclusion d-α-tocopherol might protect against ethanol-induced oxidative stress in mouse liver by directly quenching lipid peroxides,while excessive d-α-tocopherol showed no such benefits." @default.
- W2369351902 created "2016-06-24" @default.
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- W2369351902 date "2008-01-01" @default.
- W2369351902 modified "2023-09-28" @default.
- W2369351902 title "The effect of d-α-tocopherol against ethanol-induced oxidative stress in mouse liver" @default.
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