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- W2369352504 abstract "Objective To investigate the effects of Roux-en-Y gastric bypass on the asymmetric dimethylarginin(ADMA)metabolism in the kidney of type 2 diabetics rats.Methods Forty SD rats were randomly divided into normal control group(NC group n =8) and diabetes model group(n =32),30 rates were considered as successful diabetes modle.which were randomly divided into a diabetes operation group(DO,n = 14),a diabetes sham operation group(DSO,n = 8),and a diabetes control group(DC,n =8),The DO group received gastric bypass surgery and DSO group received sham operation;The glucagon like peptide-1(GLP-1) were measured before operation and at 1th,2th,4th,8th week after operation;The fasting blood glucose(FBG) were texted before operation and 8 weeks after operation;blood urea nitrogen(BUN),creatinine(Cr),nitric oxide(NO).nitric oxide synthase(NOS),ADMA were observed 8 weeks after operation,PRMT1 and DDAH1 mRNA expressions were determined by RT-PCR,The PRMT1 protein was detected by Western blotting,Kidney pathology change was observed by PAS dyeing.Results GLP-1 was increased in DO group after operation,the other groups have no signification changes(p 0.05);compared with the NC and DO groups,the FBG,BUN,Cr,ADMA,PRMT1-mRNA and protein express increased in the DC and DSO groups(P0.05),the level of NOS,NO,DDAH1 decreased(P0.05);PAS dyeing indicates that mesangial matrix increased and PAS positive content increased in DC and DSO groups,there are no changes in the NC and DO groups.Conclusion ADMA elevates in kidney tissue of Type 2 diabetes,gastric bypass operation promotes ADMA metabolism,and improves renal function." @default.
- W2369352504 created "2016-06-24" @default.
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- W2369352504 date "2014-01-01" @default.
- W2369352504 modified "2023-09-28" @default.
- W2369352504 title "Effects of Roux-en-Y Gastric Bypass on Asymmetric Dimethylarginin Metabolism in Kidney of Rats with Type 2 Diabetics" @default.
- W2369352504 hasPublicationYear "2014" @default.
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