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- W2369368055 abstract "Objective To investigate the chemopreventive effect of 5-aminosalicylic acid(5-ASA) on the inflammatory bowel disease-associated colonic cancer(IBDACa) and dysplasia(IBDADys).Methods All clinical study articles about chemoprevention of 5-ASA on IBDACa/Dys were searched by PubMed(Medline),EMCC,OVID,the Cochrane Library,Wanfang Database,VIP,CNKI and Google Scholar,the OR values and its 95% CI were calculated by RevMan software.Results 14 articles were selected for Meta-anlalysis,including 10 case-control studies and 4 cohort studies.Compared with those who didn't receive 5-ASA,the patients who received 5-ASA had a lower risk to develop IBDACa/Dys(OR=0.50,95%CI: 0.34~0.73).The case-control studies showed an OR=0.30(95% CI: 0.10~0.92),and the cohort studies showed an OR=0.56(95% CI: 0.37~0.85).Both UC patients(OR=0.45,95% CI: 0.27~0.77) and CD patients(OR=0.39,95%CI: 0.16~0.97) who received 5-ASA were less likely to develop colonic cancer or dysplasia compared with those who didn't receive 5-ASA.Conclusion 5-ASA has chemopreventive effect on IBDACa/Dys." @default.
- W2369368055 created "2016-06-24" @default.
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- W2369368055 date "2013-01-01" @default.
- W2369368055 modified "2023-09-26" @default.
- W2369368055 title "The chemopreventive effect of 5-aminosalicylic acid on inflammatory bowel disease associated colonic cancer and dysplasia: a Meta-analysis" @default.
- W2369368055 hasPublicationYear "2013" @default.
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