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- W2369370651 abstract "Objective To investigate the expression level of IL-10 in non-small cell lung cancer and its relation to IL-2,IFN-γ.Methods The expression of IL-10 was studied by RT-PCR and ELISA techniques in lung cancer cell lines,63 lung cancer tissues sampleed in operation and 31 tumor surrounding normal tissues.Lung cancer cell line was used to study the secretion of IL-10 in different exogenous factors.Results IL-10 was strongly expressed in lung cancer tissues compared with normal lung tissue;IL-2 and IFN-γ inhibited IL-10 production by lung cancer cell lines in different doses and concentration;Tumor-derived IL-10 secretion was increased significantly by exogenous recombinant cytokines including IL-4 and tumor necrosis factor α.Conclusion IL-10 is expressed in lung cancer tissue.It may may play an active immunoregulatory role in the lung cancer microenvironment." @default.
- W2369370651 created "2016-06-24" @default.
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- W2369370651 date "2000-01-01" @default.
- W2369370651 modified "2023-09-25" @default.
- W2369370651 title "Expression and Significance of IL-10 in Lung Cancer Cell and the Influencing Factors" @default.
- W2369370651 hasPublicationYear "2000" @default.
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