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- W2369388334 abstract "Aim The effects of diazepam on the whole cell sodium currents in rat sympathetic ganglion neurons were studied to investigate the mechanisms by diazepam mediates hypotension. Methods Whole cell patch clamp recordings were performed on enzymatically isolated rat superior cervical sympathetic ganglion neurons. Results Diazepam dose dependently blocked the whole cell sodium currents. Under a V t of 0 mV and a V h of 80 mV 0.3 μmol·L -1 diazepam reduced sodium peak currents by 14.76 %(P 0.01 ), with a mean IC 50 values of 6.06 μmol·L -1 (r= 0.99 , P 0.01 ); The blockade was also potential dependent (P 0.05 ), under a holding potential of 60 mV , the mean IC 50 value was 4.60 μmol·L -1 , 3.0 μmol·L -1 diazepam reduced the peak values of I V curve by 48.94 % and caused 10 mV shift of I V curve to depolarized potentials, a 0.89 mV shift of voltage dependent activation curve to depolarized potentials (P 0.05 ) and a 20.12 mV shift of the steady state inactivation curve to more hyperpolarized potentials (P 0.01 ). Following diazepam administration, the conditioning pulse potential at which half maximal channels were inactivated (V 1/2 ), was changed from -64.13 mV to -84.25 mV and the test potential at which half maximal channels were activated (V 1/2 ), was changed from -24.64 mV to -23.75 mV . Conclusion Clinically relevant concentration of diazepam has a significant inhibition on sympathetic ganglion neurons. This inhibition is dose dependent and potential dependent and relevant to the inactivation of sodium channel. The circulation depression of diazepam may be relevant to the direct suppression of sympathetic ganglion neurons." @default.
- W2369388334 created "2016-06-24" @default.
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- W2369388334 date "2001-01-01" @default.
- W2369388334 modified "2023-09-28" @default.
- W2369388334 title "Inhibitory mechanisms of diazepam on macroscopic sodium currents in rat sympathetic ganglion neurons" @default.
- W2369388334 hasPublicationYear "2001" @default.
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