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- W2369395370 abstract "Objective To explore the clinical curative effect of intrapleural injection of tissue plasminogen activator(tPA) in the prevention of loculated infected pleural effusions.Methods 32 patients with loculated effusions were randomized into 2 groups,intrapleural tPA therapy group and conventional group (control group).The patients in therapy group were injected with tPA 10 mg and saline 50 ml intrapleurally after each thoracocentesis,other therapies were similar to control group.The clinical curative effect and adverse effect were observed for the two groups.Results (1)The mean volume of fluid drained were (1020±320)ml and (630±105)ml;The mean time of admission was (14.0±5.5)d and (20.0±6.7)d;The incidence of pleural adhesion and loculation were 5 cases(33.3%) and 12 cases(70.6%) after 3 months in the therapy group and the control group respectively.There were significant difference for mean volume of fluid drained,mean time of admission and the incidence of pleural adhesion and loculation between the therapy group and control group (P0.05).(2)The mean number of fluid drained and pulmonary function indexes were significant difference between the two groups (P0.05).There was no serious adverse effect in the two groups.Conclusions Intrapleural injection of tPA can evidently increase the volume of pleural effusion drained,prevent the incidence of pleural adhesion and loculation,and improve the lung function." @default.
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- W2369395370 date "2011-01-01" @default.
- W2369395370 modified "2023-09-27" @default.
- W2369395370 title "Effectiveness and safety of intrapleural tissue plasminogen activator in the prevention of pleural thickening and loculated infected pleural effusions" @default.
- W2369395370 hasPublicationYear "2011" @default.
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