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- W2369424114 abstract "Objective:To observe the efficacy and side effects of HELF regimen combined with α-interferon in the treatment of advanced gallbladder carcinoma.Methods:24 cases with advanced gallbladder carcinoma were administrated with HELF regimen,6mg/m~2 of HCPT,60mg/m~2 of VP16,200mg/m~2 of CF and 500mg/m~2 of 5-Fu were infused intravenously on day 1 to 5. 3 million units of α -interferon was intramuscular injected every other day for at least 3 months in the former 13 cases, and administrated continuously on d1～10 after chemotherapy in the latter 11 cases because of myelosuppression and temporary drug fever. The regimen was repeated every 4 weeks and the efficacy was evaluated using WHO standard after 2 cycles of treatment.Results:All of the 24 cases were eligible for clinical response evaluation. The overall response rate was 25%,including 1 case of CR,5 cases of PR,12 cases of SD and 6 cases of PD respectively. The median survival time was 17 months. The major side effect were myelosuppression,alopecia and temporary drug fever. Conclusion:HELF combined with α-interferon is a nice regimen,meanwhile the toxicity is mild and tolerable. The sequential administration of HELF and α-interferon could reduce the incidence of side-effects." @default.
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- W2369424114 date "2005-01-01" @default.
- W2369424114 modified "2023-09-28" @default.
- W2369424114 title "Clinical study of HELF regimen combined with α-interferon in the treatment of advanced gallbladder carcinoma" @default.
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