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- W2369437239 abstract "AIM: To investigate the expression of SCL (stem cell leukemia) gene in bone marrow stromal cells (BMSCs) and bone marrow hematopoietic cells from patients with aplastic anemia (AA) and normal individuals. METHODS: Bone marrow stromal cells from AA (9 cases) and normal individuals (33 cases) were amplified by long-term in vitro culture. The adherent and nonadherent cells were collected respectively. RT-PCR-ELISA assay was then performed to detect the expression of SCL gene and the housekeeping gene β_2 microglobulin (β_2M). The expression ratio of SCL gene were analyzed and its expression level was normalized by β_2M gene acting as an internal calibration for the purpose of semi-quantitative analysis. RESULTS: The expression ratio of SCL gene was lower in BMSCs from AA (22.2%) than that in normal controls (69.7%, P0.05) and in the nonadherent cells from AA than that in their corresponding BMSCs (P0.05). Semi-quantitative analysis by PCR-ELISA showed that SCL gene expression level in nonadherent cells from normal control was significantly higher than that in their corresponding BMSCs (P0.05). CONCLUSION: The state of low expression of SCL gene in BMSCs from AA suggests that it may be involved in the abnormal regulation of hematopoiesis in AA. [" @default.
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- W2369437239 date "2005-01-01" @default.
- W2369437239 modified "2023-09-27" @default.
- W2369437239 title "Expression of SCL gene in bone marrow stromal cells from normal individuals and patients with aplastic anemia" @default.
- W2369437239 hasPublicationYear "2005" @default.
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