Matches in SemOpenAlex for { <https://semopenalex.org/work/W2369439334> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2369439334 abstract "Objective To investigate the biological activity and molecular mechanism of IFN α on human myeloma cell line U266. Methods The effect of IFN α on the growth of U266 cells was measured by MTT assay; U266 cells cycle distribution and the expression of IL 6R and gp130 on the cell surface in the absence or presence of IFN α were monitored by FACS analysis. Immunoblot assay was used in U266 cells stimulated by IFN α to detect the activation of protein kinase ERK, that is involved in Ras/MAPK signal transduction pathway mediating cell survival and proliferation. Then the changes on U266 cells proliferation and ERK activation induced by IFN α were examined in the presence of PD98059, the specific antagonist of Ras/MAPK pathway. Results IFN α promoted cell cycle progression and proliferation of U266 cells, but it did not show any effect on the expression of IL 6R and gp130 on cell surface. ERK was activated in U266 cells stimulated by IFN α, but both cell proliferation and ERK activation were obviously inhibited in the presence of PD98059. Conclusion The proliferative effect of IFN α on U266 cells is mediated by activation of protein kinase ERK. [" @default.
- W2369439334 created "2016-06-24" @default.
- W2369439334 creator A5008872506 @default.
- W2369439334 date "2002-01-01" @default.
- W2369439334 modified "2023-09-26" @default.
- W2369439334 title "Activation of protein kinase ERK mediates proliferative effect of IFN-α on human myeloma cell line U266" @default.
- W2369439334 hasPublicationYear "2002" @default.
- W2369439334 type Work @default.
- W2369439334 sameAs 2369439334 @default.
- W2369439334 citedByCount "0" @default.
- W2369439334 crossrefType "journal-article" @default.
- W2369439334 hasAuthorship W2369439334A5008872506 @default.
- W2369439334 hasConcept C1491633281 @default.
- W2369439334 hasConcept C153911025 @default.
- W2369439334 hasConcept C184235292 @default.
- W2369439334 hasConcept C185592680 @default.
- W2369439334 hasConcept C29537977 @default.
- W2369439334 hasConcept C502942594 @default.
- W2369439334 hasConcept C54355233 @default.
- W2369439334 hasConcept C55493867 @default.
- W2369439334 hasConcept C57074206 @default.
- W2369439334 hasConcept C62112901 @default.
- W2369439334 hasConcept C62478195 @default.
- W2369439334 hasConcept C81885089 @default.
- W2369439334 hasConcept C86803240 @default.
- W2369439334 hasConcept C95444343 @default.
- W2369439334 hasConcept C97029542 @default.
- W2369439334 hasConceptScore W2369439334C1491633281 @default.
- W2369439334 hasConceptScore W2369439334C153911025 @default.
- W2369439334 hasConceptScore W2369439334C184235292 @default.
- W2369439334 hasConceptScore W2369439334C185592680 @default.
- W2369439334 hasConceptScore W2369439334C29537977 @default.
- W2369439334 hasConceptScore W2369439334C502942594 @default.
- W2369439334 hasConceptScore W2369439334C54355233 @default.
- W2369439334 hasConceptScore W2369439334C55493867 @default.
- W2369439334 hasConceptScore W2369439334C57074206 @default.
- W2369439334 hasConceptScore W2369439334C62112901 @default.
- W2369439334 hasConceptScore W2369439334C62478195 @default.
- W2369439334 hasConceptScore W2369439334C81885089 @default.
- W2369439334 hasConceptScore W2369439334C86803240 @default.
- W2369439334 hasConceptScore W2369439334C95444343 @default.
- W2369439334 hasConceptScore W2369439334C97029542 @default.
- W2369439334 hasLocation W23694393341 @default.
- W2369439334 hasOpenAccess W2369439334 @default.
- W2369439334 hasPrimaryLocation W23694393341 @default.
- W2369439334 hasRelatedWork W134051291 @default.
- W2369439334 hasRelatedWork W1983947689 @default.
- W2369439334 hasRelatedWork W1986785442 @default.
- W2369439334 hasRelatedWork W1994340144 @default.
- W2369439334 hasRelatedWork W2013290841 @default.
- W2369439334 hasRelatedWork W2018553909 @default.
- W2369439334 hasRelatedWork W2019665042 @default.
- W2369439334 hasRelatedWork W2031427369 @default.
- W2369439334 hasRelatedWork W2041801575 @default.
- W2369439334 hasRelatedWork W2042524910 @default.
- W2369439334 hasRelatedWork W2050952832 @default.
- W2369439334 hasRelatedWork W2053894673 @default.
- W2369439334 hasRelatedWork W2085141195 @default.
- W2369439334 hasRelatedWork W2104360930 @default.
- W2369439334 hasRelatedWork W2131280544 @default.
- W2369439334 hasRelatedWork W2134199689 @default.
- W2369439334 hasRelatedWork W2764856911 @default.
- W2369439334 hasRelatedWork W2990169509 @default.
- W2369439334 hasRelatedWork W2742123609 @default.
- W2369439334 hasRelatedWork W3031264727 @default.
- W2369439334 isParatext "false" @default.
- W2369439334 isRetracted "false" @default.
- W2369439334 magId "2369439334" @default.
- W2369439334 workType "article" @default.