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- W2369439733 abstract "Objective To study the combination effect of low dose cisplatin and 32P-GMS on treating experimental mice solid tumor S180 and to observe apoptosis of the tumor cells. Methods The mice with the solid tumor S180 were divided into control group, DDP group, 32P-GMS group, and combination group (DDP and 32P-GMS) randomly. The weight of tumor was measured separately after two weeks and the cell divide cycle of each group and the rate of apoptosis were detected by FCM. Results The inhibition rates of DDP group, 32P-GMS group and combination group were 47%, 40%, and 76% respectively, and the apoptosis rates of tumor cells were 21.43%, 37.64%, and 62.03% respectively. The apoptosis rates of the experimental groups were significantly higher than that of the control group (P0.05). The apoptosis rate of combination group was significantly higher than those of DDP group and 32P-GMS group (P0.001). Conclusion Low dose cisplatin can obviously enhance the inhibiting effect of 32P-GMS. This provides theoretical basis for the clinical use of low dose cisplatin combined with 32P-GMS." @default.
- W2369439733 created "2016-06-24" @default.
- W2369439733 creator A5082931259 @default.
- W2369439733 date "2004-01-01" @default.
- W2369439733 modified "2023-09-25" @default.
- W2369439733 title "Study of the Anti-tumor Effects of Interstitial Radiotherapy with ~(32)P Glass Microspheres in Combination with Low Dose Cisplatin on Experimental Mice Solid Tumor S180." @default.
- W2369439733 hasPublicationYear "2004" @default.
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