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- W2369452682 abstract "【Objective】 To investigate the effect of chromosomal translocations on the embryo development and the possible mechanism. 【Methods】 31 Robertsonian and 48 Reciprocal PGD cycles conducted in the First Affiliated Hospital of Sun Yat-sen University during June 2010 to December 2012 were included. Embryos ' development in normal / balanced group and abnormal group were retrospectively analyzed, compared with α-thalassemia PGD cycles. Embryos' development in different gender and translocation group were also measured. 【Result】 No significant difference was found between normal / balanced and unbalanced embryo group in terms of D3 high-quality embryo percentage,79.5% vs 71.1% in Rob and 77.3% vs 72.0% in REC, respectively. The percentage of blastocyst at D5-D6 was significantly higher in the normal / balanced group, 76.9% vs 53.5% in Rob and 75.0% vs 55.6% in REC(P 0.0001). No significance was found about the embryo development in different subgroups divided by gender and acrocentric chromosome.【Conclusion】 Unbalanced chromosome has little effects on early embryos 's development. A self-elimination mechanism may exist during the blastulation stage. Geuder and acrocentric chromosome may have little effects on the rates of normal / balanced embryos and their development." @default.
- W2369452682 created "2016-06-24" @default.
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- W2369452682 date "2013-01-01" @default.
- W2369452682 modified "2023-09-26" @default.
- W2369452682 title "Effect of Chromosomal Translocations on Embryo Development in PGD Cycles" @default.
- W2369452682 hasPublicationYear "2013" @default.
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