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- W2369454098 abstract "Objective: The purpose of this study was to identify the effect of different dose rate and expasure time on the tumor cells,which can provide a series of direction for the targeted radionuclide therapy applying low dose rate beta irradiation.Methods: Three tumor cell lines,U-118MG gliomas,A-431 cervical squamous carcinoma and SKBR-3 breast cancer,were used.An experimental model with 103 tumor cells in each sample was irradiated with low dose rate beta particles.The initial dose rates were in the range of 0.1 Gy/h~0.8 Gy/h,and the cells were continuously exposed for 1day,3days or 7days.Results: Continuous irradiation with dose rates of 0.2 Gy/h~0.3 Gy/h and 0.4 Gy/h~0.6 Gy/h for 7days and 3 days,respectively,could kill all cells in all tumor cell samples.The given total radiation doses was 30 Gy~40 Gy.However,when exposed for 24 h with about 0.8 Gy/h,only the SKBR-3 cells were successfully treated and all the other cell types recovered.Conclusions: The results served as a guideline for the combinations of dose rate and exposure time.It is necessary to kill tumor cells that low dose rate beta irradiation should be applied." @default.
- W2369454098 created "2016-06-24" @default.
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- W2369454098 date "2007-01-01" @default.
- W2369454098 modified "2023-10-03" @default.
- W2369454098 title "Study of Radiation Effects on Targeting Therapy in Nanometer-iron Nuclide" @default.
- W2369454098 hasPublicationYear "2007" @default.
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