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- W2369456171 abstract "Objective To investigate the relationship between the degree of 99mTc-methoxyas/butylisoni-trile ( MIBI) uptake and expression of multidrug-resistant protein MRP,TOPO-Ⅱ in patients with breast cancer.Methods Sixty patients with untreated breast cancer were studied prospectively.After intravenous administration of 740MBq 99mTc-MIBI,anterior planar Scintigraphy was ac-quired at 20min and 120min after injection.Such indexes as early uptake radio,delay uptake radio and retention index ( RI% ) were calculated respectively.Immunohistochemical analysis was used to evaluate the expression of MRP and TOPO-Ⅱ.Results The positive rate of 99mTc-MIBI in the patient with breast cancer was 93.33% .The positive expression rates of MRP and TOPO-Ⅱ were respectively 58.93% and 67.86% ( P0.05) .Conclusions The study suggests that 99mTc-MIBI scintigraphy may not predict the MDR development associated with MRP,TOPO-Ⅱ expression in breast cancer." @default.
- W2369456171 created "2016-06-24" @default.
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- W2369456171 date "2010-01-01" @default.
- W2369456171 modified "2023-09-24" @default.
- W2369456171 title "The study on relationship between ~(99m)Tc-MIBI scinigraphy of breast cancer and expression of MRP and TOPO-II" @default.
- W2369456171 hasPublicationYear "2010" @default.
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