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- W2369493808 abstract "Objective:To observe the effect of donepezil hydrochloride on the changes about extracellular signal-regulated kinase(ERK1 and ERK2)at the hippocampus of mice with vascular dementia(VD).Methods:Kunming mice were divided into sham group,model group and treatment group with donepezil hydrochloride randomly.The models of VD mice were established through three times ischemia-reperfusion of bilateral common carotid arteries.The mice from drug group were treated with donepezil hydrochloride.The behavioral scores of three groups were investigated by step-down test and water maze test at days 29,30 respectively.The expressing changes of ERK1,ERK2 in hippocampus CA1 were observed by immunohistochemistry technique.Results:The grades of learning and memory of VD mice were obviously improved by donepezil hydrochloride(p0.05).The expression of ERK1,ERK2 in hippocampus CA1 was significantly lower in the model group than that in the sham group(p0.05)and the drug group(p0.05).Conclusion:The decreased expression of ERK1 and ERK2 may participate the pathogenesis of vascular dementia,Donepezil hydrochloride could increase the content of acetylcholine which could activate ERK through M receptor and furthermore improve abilities of learning and memory." @default.
- W2369493808 created "2016-06-24" @default.
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- W2369493808 date "2008-01-01" @default.
- W2369493808 modified "2023-09-23" @default.
- W2369493808 title "The Effect of Donepezil Hydrochloride on the Changes about ERK1 and ERK2 at the Hippocampus of Mice with Vascular Dementia" @default.
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