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- W2369536700 abstract "Objective To investigate the state of oxidative stress in the subjects with different levels of serum uric acid and to explore the cause of endothelial dysfunction induced by hyperuricemia in elderly males.Methods Male elderly subjects with normal serum uric acid or hyperuricemia were enrolled in the study.According to the levels of serum uric acid,all the participants were divided into five groups.Every group consisted of about 50 subjects.Plasma malondialdehyde (MDA) ,superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined.In the mean time,plasma nitric oxide (NO) ,plasminogen activator inhibitor-1 (PAI-1) ,endothelin-1 (ET-1) and other biochemical variables were also determined.Results When the serum uric acid level was more than 380 μmol/L,the levels of plasma MDA,SOD,GSH-Px,PAI-1 and ET-1 became higher,while the that of NO became lower (P0.05) .Moreover,SOD and GSH-Px became much lower when the serum uric acid level was more than 420 μmol/L.Multivariate stepwise regressive analysis showed that PAI-1 was positively related to MDA,UA,HOMA-IR and TG,but negatively related to SOD and NO (t=-3.65 through-6.08,P0.05) .ET-1 was positively related to MDA,UA and HOMA-IR,and negatively related to NO,GSH-Px and SOD (t=-4.74 through-6.35,P0.05) .Conclusion It is indicated that oxidative stress will become obvious when the serum uric acid level is over 380 μmol/L in elderly males.Oxidative stress,high serum uric acid level and insulin resistance may be involved in endothelial dysfunction." @default.
- W2369536700 created "2016-06-24" @default.
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- W2369536700 date "2010-01-01" @default.
- W2369536700 modified "2023-09-23" @default.
- W2369536700 title "Study of oxidative stress and endothelial dysfunction induced by hyperuricemia in elderly males" @default.
- W2369536700 hasPublicationYear "2010" @default.
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