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- W2369547604 abstract "Objective To study the effects of tea polyphenols(TP)on lung cancer cell line SPC-A1 proliferation and cell cycle in vitro.Methods SPC-A1 cell line were treated with TP at 50～300mg/L.Cell proliferation were evaluated by MTT and apoptosis by electric microscope,blockage of cell cycle by flow cytimetry in vitro.Results The proliferation of SPC-A1 were significantly inhibited by tea polyphenols and the inhibitionrate was time-dependent(12～36h) and concentration-dependent(50～150mg/L).Its inhibitory effect decreased when the concentration exceeds 150mg/L.Typical nuclear condensation was observed by tranmissional electron microscope and SPC-A1 cells were blocked in G_1 phaes.The highest G_1 peak was detected at the concentration of 150mg/L after 24h.Conclusion TP can inhibited the proliferation of SPC-A1 in vitro,by inducing cancer cell apoptosis and blocking cell cycle." @default.
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- W2369547604 date "2006-01-01" @default.
- W2369547604 modified "2023-09-30" @default.
- W2369547604 title "The effects of tea polyphenols on proliferation and cell cycle of cell line SPC-A1 in lung cancer" @default.
- W2369547604 hasPublicationYear "2006" @default.
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