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- W2369558428 abstract "【Objective】To investigate the dynamic expression of integrin α1 in CCl4-intoxicated rat liver,and to explore the effect and significance of schisandrin on expression of integrin α1 in CCl4-intoxicated rat hepatocytes.【Methods】The Wistar rats were randomly divided into the control group,the intoxicated group and the treated group.The rats of intoxicated and treated groups were given a single dosage(0.2mL/100g body mass) of peritoneal injection of CCl4(200 mL/L in vegetable oil) to establish rat models of acute hepatic injury.The rats of treated group were given the extract of schisandrin(0.5 mL/100g) by intragastric administration once daily.The rats of intoxicated group were treated with normal saline(0.5 mL/100g) instead.The rats were sacrificed at different time pionts.The expression of integrin α1 in the hepatic tissue of all three groups was detected by RT-PCR and immunohistochemical method.【Results】 It showed that the expression of integrin α1 mRNA and protein in rat hepatocytes of the treated group was significantly increased compared with that of the intoxicated group.The difference between the two groups was statistically significant(P0.05).【Conclusion】Schisandrin for the treatment of acute hepatic injury induced by CCl4 can promote the expression of integrin α1 mRNA and protein in hepatocytes,which suggests that the protective effect of schisandrin on rat liver is associated with regulation of metabolism of integrin α1 in hepatic tissue." @default.
- W2369558428 created "2016-06-24" @default.
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- W2369558428 date "2008-01-01" @default.
- W2369558428 modified "2023-09-23" @default.
- W2369558428 title "Effect of Schisandrin on Expression of Integrin α1 in Hepatic Tissue of CCl_4-intoxicated Rats" @default.
- W2369558428 hasPublicationYear "2008" @default.
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