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- W2369567682 abstract "Aim Synthesis the key intermediate of rosuvastatin 4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-carboxylate.Method Synthesized from methyl isobutyrylacetate by condensation with 4-fluorobenzaldehyde,cylization with S-methylisothiourea sulfate,oxygenation by potassium permanganate,and substitution by methylamine and methanesulfonyl chloride respectively.Result The total yield of five steps is 25.0%.Conclusion Improve the synthetic methods and it is available to the synthesis of rosuvastatin." @default.
- W2369567682 created "2016-06-24" @default.
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- W2369567682 date "2004-01-01" @default.
- W2369567682 modified "2023-09-23" @default.
- W2369567682 title "Synthesis of 4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-carboxylate" @default.
- W2369567682 hasPublicationYear "2004" @default.
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